Electrophysiological devices are critical for mapping both healthy and pathological areas of the brain, and for facilitating therapeutic neuromodulation in medical practices. Additionally, they are extensively used in brain-machine interfaces, highlighting their critical role in both healthcare and research. However, current devices frequently fall short in terms of spatial resolution or the extent of cortical coverage they can provide. To address these limitations, we engineered the PtNRGrid, an advanced micro-ECoG grid, through the application of sophisticated nanofabrication methods and enhanced connectorization strategy. This thin-film neurophysiological recording electrode features thousands of channels and has been successfully applied to human brains in intraoperative settings. This micro-ECoG grid, enhanced by low impedance platinum-nanorods, offers excellent electrocorticography recording with unprecedented spatial resolution and cortical coverage.
Furthermore, to provide automated and real-time feedback directly from the cortical surface for efficacious and high-precision neurosurgery, we integrated a flexible micro-LED display with the micro-ECoG grid. This system not only captures intricate brain dynamics with high precision but also visualizes functional brain boundaries and epileptic discharges on the cortical surface. This integration of micro-ECoG grid with micro-LED array represents a substantial advancement in neurotechnology, empowering surgeons to conduct surgeries with high precision and efficiency, guided by high-resolution functional mapping of brain and real-time cortical feedback.

첨부: 뇌과학세미나 포스터(2024-1)