[뇌과학세미나 초청강연 소식] 12월 12일 KAIST 생명과학과 손종우 교수님 - 공지 사항 - 자연대 알림

- 제목: Identifying appetite-promoting function of hypothalamic POMC neurons
- 연사: 손종우 교수님 (KAIST 생명과학과)
- 초청자 : 김성연 교수님 (서울대학교 화학부)
- 일시: 2024년 12월 12일 (목) 오전 11시
- 장소: 서울대학교 관악캠퍼스 자연과학대학 28동 303호
- 링크: https://snu-ac-kr.zoom.us/j/83749302527?pwd=K9OklhrJ1QataDeE9hYnKhKS87Kmyf.1
회의 ID: 837 4930 2527 암호: 930771

- Abstract :

Orexin (or hypocretin) is a hypothalamic neuropeptide that regulates wakefullness and appetite. While it was initially suggested that orexin promotes feeding by the hypocretin receptor (Hcrtr) expressed by hypothalamic neurons, the identity of responsible neural population and the relevant circuits still remain to be identified. Interestingly, Hcrtr2 is highly expressed by the anorexigenic pro-opiomelanocortin (POMC) neurons, but the role of Hcrtr2 expressed by POMC neurons remains unclear. In this study, we investigated the neural mechanisms for orexin-induced hyperphagia. We used multiple approaches including patch-clamp electrophysiology, immunohistochemistry, MERFISH, and in vivo feeding studies to gain insight into the neuronal circuits responsible for the orexigenic effects of orexin A. We found that applications of orexin A directly depolarize a distinct subpopulation of POMC neurons. In addition, in vivo experiments demonstrated that Hcrtr2 expressed by the POMC neurons is responsible for the orexigenic effects of orexin A. We also identified the neural circuit downstream of POMC neurons and found evidence that opioid receptors are involved in the effects of orexin A. Finally, we found that orexin A-activated POMC neurons constitute a distinct subpopulation within the arcuate nucleus of the hypothalamus. Together, our findings demonstrate that orexin A increases food intake via the activation of a distinct subpopulation of arcuate POMC neurons and the downstream neural circuits.

문의: 협동과정 뇌과학전공 Tel 02-880-4358

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